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Too much IV fluid in trauma?

It would seem to make sense that injured and bleeding patients need fluids, don’t they? Blood or saline can replace lost blood and restore normal cardiovascular function and oxygen delivery, according to traditional teaching.  When your bleeding patient is pale and has a low blood pressure and a weak pulse it is hard not to intervene. On the other hand, much published research – e.g. Bickell’s 1994 randomized controlled trial showing increased death in penetrating trauma patients who had received pre-hospital IV fluids  – challenges the view that normalizing blood pressure in trauma patients is a good idea. Unfortunately, little change in practice has occurred since Bickell’s classic study.

A recent study by Schrieber and colleagues in the Journal of Trauma and Acute Care Surgery again tested which approach to blood pressure in trauma is better for survival: 1)  standard treatment, which involves aggressive provision of IV fluids aimed at normalizing blood pressure; 2) a less aggressive approach that permits blood pressure to remain low (called controlled resuscitation or CR here).

Spoiler alert: Patients given less fluid, with lower blood pressure, had better survival in the blunt trauma group, though no differences were seen in penetrating trauma.

The abstract is here:

BACKGROUND: Optimal resuscitation of hypotensive trauma patients has not been defined. This trial was performed to assess the feasibility and safety of controlled resuscitation (CR) versus standard resuscitation (SR) in hypotensive trauma patients.

METHODS: Patients were enrolled and randomized in the out-of-hospital setting. Nineteen emergency medical services (EMS) systems in the Resuscitation Outcome Consortium participated. Eligible patients had an out-of-hospital systolic blood pressure (SBP) of 90 mm Hg or lower. CR patients received 250 mL of fluid if they had no radial pulse or an SBP lower than 70 mm Hg and additional 250-mL boluses to maintain a radial pulse or an SBP of 70 mm Hg or greater. The SR group patients received 2 L initially and additional fluid as needed to maintain an SBP of 110 mm Hg or greater. The crystalloid protocol was maintained until hemorrhage control or 2 hours after hospital arrival.

RESULTS: A total of 192 patients were randomized (97 CR and 95 SR). The CR and SR groups were similar at baseline. The mean (SD) crystalloid volume administered during the study period was 1.0 L (1.5) in the CR group and 2.0 L (1.4) in the SR group, a difference of 1.0 L (95% confidence interval [CI], 0.6–1.4). Intensive care unit–free days, ventilator-free days, renal injury, and renal failure did not differ between the groups. At 24 hours after admission, there were 5 deaths (5%) in the CR group and 14 (15%) in the SR group (adjusted odds ratio, 0.39; 95% CI, 0.12–1.26). Among patients with blunt trauma, 24-hour mortality was 3% (CR) and 18% (SR) with an adjusted odds ratio of 0.17 (0.03–0.92). There was no difference among patients with penetrating trauma (9% vs. 9%; adjusted odds ratio, 1.93; 95% CI, 0.19–19.17).

CONCLUSION: CR is achievable in out-of-hospital and hospital settings and may offer an early survival advantage in blunt trauma. A large-scale, Phase III trial to examine its effects on survival and other clinical outcomes is warranted.

LEVEL OF EVIDENCE: Therapeutic study, level I.

How does adaptation and natural selection play into these findings? Read: Turning off the tap – less is more in fluid resuscitation by Joe Alcock – The Sharp End 2012

Categories: Uncategorized

Joe Alcock

Emergency Physician, Educator, Researcher, interested in the microbiome, evolution, and medicine

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