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Whiskey is for drinking, glucose is for fighting over

Many infections, including sepsis, trigger insulin resistance and hyperglycemia. Chronic viral and atypical bacterial infections, such as HSV-2 and Chlamydia pneumonia, are associated with high blood sugar and insulin resistance. Other viral illnesses, including hepatitis C infection and HIV also induce insulin resistance. In the case of HIV, research suggests that these findings […]

2023 UNM Evolutionary Medicine

Three learning objectives will be the focus of 2023’s evolutionary medicine elective. Priority 1. We will discuss “tree thinking” and learn the evolutionary principle of common descent. Our shared evolutionary legacy is the basis for the One Health movement that seeks to bridge the gap between human and veterinary medicine […]

Endogenous retroviruses and aging

The two main evolutionary concepts I teach students about aging are George C. Williams’ idea of antagonistic pleiotropy and the declining power of selection hypothesis (aka selection shadow hypothesis) proposed by J.S. Haldane and Peter Medawar in the 1940s and 1950s. Medawar posited that beneficial genes, coding for body maintenance […]

Microbes control eating behavior?

In 2014, Carlo Maley, Athena Aktipis, and I wrote an article on eating behavior and the gut microbiota that was published in Bioessays. We proposed that unhealthy food preferences, cravings and aversions may serve the evolutionary interests of microbes in our guts, sometimes in conflict with our own interests. We suggested […]

The eyes have it

Eerie! Watch the NASA animation of the space probe Dawn approaching the dwarf planet Ceres. Eyes, right! When I saw this it reminded me of a moment hiking down a red rock canyon in Utah. I looked up and suddenly saw this: When I saw the pictograph, and when I […]

Life history theory and the microbiome

This is a re-post of a previous entry, now updated. Life history theory, a concept first described by Yale evolutionary biologist Stephen Stearns, is the application of evolutionary biology to the entire life cycle from birth to death. It includes the hypothesis that features of life are shaped by natural […]

Live free and die

Disease is a ubiquitous feature of life on earth. All biological life on the plant evolved. Diseases evolved too. Problem is, diseases are fitness reducing for their hosts. By that definition, diseases are maladaptive. Yet the motor of evolution, natural selection, favors traits that are adaptive, not maladaptive. Why then, […]