During normal functioning, adequate delivery of oxygen and blood flow is prioritized to body organs. Oxidation of glucose is the dominant means by which mitochondria in our cells generate ATP, the main currency of energy in the body. Because of the importance of oxygen and blood flow, human physiology comes […]
Coffee Brown and I recorded a podcast last year about the surprising result of a large systematic review of oxygen therapy – the IOTA trial. The IOTA trial showed a lack of benefit, often in the direction of harm, from one of our most common medical interventions – supplemental oxygen. Giving […]
Should we consider fever a “new normal” during infection? Should we treat it or not? A 2017 observational study of emergency department patients revealed this intriguing pattern:In the above study of 2225 patients with sepsis in Sweden, a lack of fever or low body temperature heralded a poor prognosis in […]
Does the emperor have no clothes? In a recent manuscript published in the Journal of Clinical Medicine, I challenge the concept of dysregulation that is at the core definition of sepsis. Listen to the EvolutionMedicine podcast #36 for a full discussion of the provocative idea that sepsis is a regulated […]
For week three of the UNM Evolutionary Medicine class we will discuss behavioral changes that happen with infection and sickness. One of my favorite topics is sickness behavior. Many different species alter their activity level, feeding behavior, and engage in novel behaviors that do not occur in health. Even caterpillars […]
Update: a research study performed by Abou-Jaoude and colleagues presented on November 16th at the American College of Allergy Asthma and Immunology examines the link between maternal “mouth cleaning” of infant pacifiers and allergy. They found that “parental pacifier sucking was linked with suppressed IgE levels” in infants. Lower IgE […]
The Evolutionary Medicine Elective for UNM Medical Students starts today. We will begin by discussing this paper by Steve Stearns: Evolutionary medicine: its scope, interest, and potential. Read that article carefully prior to the first session. Week One will focus on the evolution of antibiotic resistance and the […]
The Zombie Apocalypse (Medical Meeting) is about to start! Where – the great state of Arizona. The first stirrings of the apocalypse will be at the Arizona State University. I along with several of my emergency medicine colleagues will be on hand to give medical and disaster tips in preparation […]
“Vague Presenting Symptoms Are Associated with Increased Mortality in Septic Shock” is the title of a recent entry of Journal Watch, a section of the New England Journal of Medicine written by emergency physician Daniel Lindberg. Lindberg summarizes findings of Filbin et al. Presenting Symptoms Independently Predict Mortality in Septic […]
Why do we sleep? How much is enough? Do we die if we don’t get enough? Kate Rusk, Joe Alcock, Coffee Brown and Gandhi Yetish discuss these topics in this episode of the EvolutionMedicine podcast. Sleep is one of the least understood lifestyle-related risk factor for chronic disease. For instance, […]
