A recent meta analysis concluded that statins, though effective at reducing cholesterol, are not helpful in sepsis. Statins have a variety of anti-inflammatory effects that were hypothesized to reduce harmful host inflammation in sepsis. It did not work. Read the results here:
Thomas. Statin therapy in critically-ill patients with severe sepsis: a review and meta-analysis of randomized clinical trials. Minerva Anestesiologica 2015;epublished February 18th
Does this mean inflammation is not on balance bad for us in sepsis? Regulation of inflammation during sepsis might not be out of control at all. Inflammation in sepsis, though apparently costly and sometimes fatal is something that we should not interfere with using drug therapy, except with antibiotics. That conclusion can be derived from the failure of multitudes of anti-inflammatory treatments tried in sepsis, described in Marshall Why have clinical trials in sepsis failed? Trends Mol Med 2014
Old ideas die hard, though, and we will continue to document the failure of these interventions for sepsis on this blog as they are reported.
Emergency Physician, Educator, Researcher, interested in the microbiome, evolution, and medicine
Metabolic Theory of Septic Shock
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