Humans engage in extreme activities in extreme environments. There is no question that some of things we do are so radically different from what our hominin ancestors experienced. As a result,  selection has not had time to modify their effects. Two examples:

Footage of Felix Baumgartner’s leap from the edge of space.

Joe Namath: None of the human body is designed for football

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Joe Alcock

Emergency Physician, Educator, Researcher, interested in the microbiome, evolution, and medicine