Evolutionary Medicine and Chronic Inflammation

R. Straub published an article entitled Evolutionary medicine and chronic inflammatory state–known and new concepts in pathophysiology last year in which he argues that chronic inflammatory diseases – responsible for the bulk of cardiovascular disease in humans – are caused by re-directed energy stores to the activated immune system. Re-allocation of energetic resources to immunity is a central part of arguments we have explored previously on this blog: for example herehere, and here.

I should note that my co-author Ed Legrand and I have criticized part of Straub’s arguments in our 2012 paper in the Quarterly Review of Biology, Turning Up The Heat, Immune Brinksmanship in the Acute Phase Response. I will elaborate more on that this afternoon.

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