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Immune compromises

Why does the immune system over-react and sometimes kill us? This is a conundrum that has attracted much attention, at least from evolutionary biologists. One explanation is the smoke detector principle. It is often better to over-react than to under-react. Here is a summary that I wrote in the evolution […]

Why is hypoxia pro-inflammatory?

Posing “why” questions is a classic approach in evolutionary medicine. I have been interested in why oxygen regulates the immune system since medical school when I learned about diving and hyperbaric medicine and high altitude medicine. For both, oxygen treatment plays a key role. High altitude illnesses share many of […]